期刊
ACS NANO
卷 6, 期 1, 页码 888-896出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn204397q
关键词
intracellular; redox; SERS; nanosensor
类别
资金
- EaStCHEM
- School of Chemistry at the University of Edinburgh
- Medical Research Council [G0901697] Funding Source: researchfish
- MRC [G0901697] Funding Source: UKRI
Redox homeostasis and signaling are critically important In the regulation of cell function. There are significant challenges in quantitatively measuring intracellular redox potentials, and In this paper, we introduce a new approach. Our approach is based on the use of nanosensors which comprise molecules that sense the local redox potential, assembled on a gold nanoshell. Since the Raman spectrum of the sensor molecule changes depending on its oxidation state and since the nanoshell allows a huge enhancement of the Raman spectrum, intracellular potential can be calculated by a simple optical measurement. The nanosensors can be controllably delivered to the cytoplasm, without any toxic effects, allowing redox potential to be monitored in a reversible, non-invasive manner over a previously unattainable potential range encompassing both superphysiological and physiological oxidative stress.
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