期刊
ACS NANO
卷 5, 期 6, 页码 4790-4799出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn200768c
关键词
hydroxyapatite; carbon nanotubes; osseointegration; bone induction in vivo; elastic modulus; titanium implants
类别
资金
- National Science Foundation [NSF-DMI-0547178]
- Office of Naval Research [N00014-06-0675]
- University Graduate School, Florida International University
- Alsace contre le Cancer
- Faculte de Chirurgie Dentaire of Strasbourg
This is the first in vivo study of plasma-sprayed carbon nanotube (CNT)-reinforced hydroxyapatite (HA) coating on titanium implants embedded in rodents' bone. No adverse effect or cytotoxicity of CNT addition on bone tissues and cells was observed. Normal bone growth was observed around HA-CNT-coated implants. CNT addition induces higher osseointegration as compared to HA. Elastic modulus of new bone was compared with the modulus of HA-CNT/bone Interface to understand the mechanical integrity of the implant.
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