期刊
ACS NANO
卷 5, 期 9, 页码 7124-7129出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn201822b
关键词
iron oxide; magnetic nanoparticles; intracellular magnetic fluid hyperthermia; epidermal growth factor; epidermal growth factor receptor; alternating magnetic field
类别
资金
- U.S. National Science Foundation [CBET-0609117, HRD-0833112]
- Direct For Education and Human Resources
- Division Of Human Resource Development [833112] Funding Source: National Science Foundation
It is currently believed that magnetic nanoparticle heaters (MNHs) can kill cancer cells only when the temperature is raised above 43 degrees C due to energy dissipation in an alternating magnetic field. On the other hand, simple heat conduction arguments indicate that in small tumors or single cells the relative rates of energy dissipation and heat conduction result in a negligible temperature rise, thus limiting the potential e MNHs in treating small tumors and metastatic cancer. Here we demonstrate that internalized MNHs conjugated to epidermal growth factor (EGF) and which target the epidermal growth factor receptor (EGFR) do result in a significant (up to 99.9%) reduction in cell viability and clonogenic survival in a thermal heat dose dependent manner, without the need for a perceptible temperature rise. The effect appears to be cell type specific and indicates that magnetic nanoparticles in alternating magnetic fields may effectively kill cancer cells under conditions previously considered as not possible.
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