期刊
ACS NANO
卷 5, 期 6, 页码 5094-5099出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn201171r
关键词
near-infrared; light-responsive; nanorods; DNA cross-linked; nanogels; targeted drug delivery
类别
资金
- NIH [GM 066137, GM079359]
- State of Florida Center for Nano-Biosensors and China Grand [2009ZX10004-312]
- National Tsing Hua University [99N2947E1]
- National Science Council of Taiwan, ROC [98-2113-M-007-003, 99-2113-M-007-006-MY2]
- National Nature Science Foundation of China [20975012]
- 111 Project in China [B07012]
A near-infrared light-responsive drug delivery platform based on Au-Ag nanorods (Au-Ag NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity has been applied to develop a polyacrylamide-based sol gel transition system to encapsulate anticancer drugs Into the gel scaffold. The Au-Ag NR-based nanogels can also be readily functionalized with targeting moieties, such as aptamers, for specific recognition of tumor cells. When exposed to NIR irradiation, the photothermal effect of the Au-Ag NRs leads to a rapid rise in the temperature of the surrounding gel, resulting in the fast release of the encapsulated payload with high controllability. In vitro study confirmed that aptamer-functionalized nanogels can be used as drug carriers for targeted drug delivery with remote control capability by NIR light with high spatial/temporal resolution.
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