期刊
ACS NANO
卷 5, 期 7, 页码 5408-5416出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn200489j
关键词
bioelectronics; vapor sensor; olfactory receptor proteins; field effect transistor; nanotube
类别
资金
- DARPA
- Nano/Bio Interface Center [NSF NSEC DMR08-32802]
- Department of Defense PCRP [PC080542P1]
We have designed and implemented a practical nanoelectronic interface to G-protein coupled receptors (GPCRs), a large family of membrane proteins whose roles in the detection of molecules outside eukaryotic cells make them important pharmaceutical targets. Specifically, we have coupled olfactory receptor proteins (ORs) with carbon nanotube transistors. The resulting devices transduce signals associated with odorant binding to ORs in the gas phase under ambient conditions and show responses that are in excellent agreement with results from established assays for OR ligand binding. The work represents significant progress on a path toward a bioelectronic nose that can be directly compared to biological olfactory systems as well as a general method for the study of GPCR function in multiple domains using electronic readout.
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