期刊
ACS NANO
卷 5, 期 11, 页码 8649-8655出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn202291k
关键词
nanoparticles; cisplatin; drug delivery; nucleoside-lipids; cancer
类别
资金
- French National Agency (ANR) [ANR-08-EBIO-013-01]
- Army Research Office
The use of delivery vehicles to selectively transport anticancer agents to tumors is very attractive to address both toxicity and efficacy issues. We report a novel approach based on hybrid nucleoside lipids allowing the efficient encapsulation and delivery of cisplatin. We demonstrate that the nucleoside polar heads guide the self-assembly of the aggregates into highly loaded and stable nanoparticles. The nanoparticles, which are efficient vehicles for the delivery of cisplatin into different sensitive and resistant cancer cell lines, can overcome the disadvantages and limitations of drug delivery systems previously reported.
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