期刊
ACS NANO
卷 6, 期 1, 页码 276-285出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn2035457
关键词
gold; nanoparticle; high-density lipoprotein; cholesterol efflux; biomimic; atherosclerosis
类别
资金
- Howard Hughes Medical Institute
- Northwestern University
- NCI-CCNE at Northwestern University
- NSF NSEC
- Air Force Office of Scientific Research
- NCI CCSG [P30 CA060553]
- NATIONAL CANCER INSTITUTE [U54CA151880, P30CA060553, R01CA167041] Funding Source: NIH RePORTER
Gold nanoparticles (Au NPs) were employed as templates to synthesize spherical, high-density lipoprotein (HDL) blomimics (HDL Au NPs) of different sizes and surface chemistries. The effect of size and surface chemistry on the cholesterol binding properties and the ability of the HDL Au NPs to efflux cholesterol from macrophage cells were measured. Results demonstrate that Au NPs may be utilized as templates to generate nanostructures with different physical characteristics that mimic natural HDL. Furthermore, the properties of the HDL Au NPs may be tailored to modulate the ability to bind cholesterol in solution and efflux cholesterol from macrophages. From the conjugates tested, the optimum size and surface chemistry for preparing functional Au NP-templated HDL biomimics were identified.
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