期刊
ACS NANO
卷 4, 期 10, 页码 5731-5736出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn101390x
关键词
graphene; nanowalls; electrophoretic deposition; toxicity; bacteria; RNA efflux
类别
资金
- Research Council of Sharif University of Technology
- Iran Nanotechnology Initiative Council
Bacterial toxicity of graphene nanosheets in the form of graphene nanowalls deposited on stainless steel substrates was investigated for both Gram-positive and Gram-negative models of bacteria. The graphene oxide nanowalls were obtained by electrophoretic deposition of Mg2+-graphene oxide nanosheets synthesized by a chemical exfoliation method. On the basis of measuring the efflux of cytoplasmic materials of the bacteria, it was found that the cell membrane damage of the bacteria caused by direct contact of the bacteria with the extremely sharp edges of the nanowalls was the effective mechanism in the bacterial inactivation. In this regard, the Gram-negative Escherichia coli bacteria with an outer membrane were more resistant to the cell membrane damage caused by the nanowalls than the Gram-positive Staphylococcus aureus lacking the outer membrane. Moreover, the graphene oxide nanowalls reduced by hydrazine were more toxic to the bacteria than the unreduced graphene oxide nanowalls. The better antibacterial activity of the reduced nanowalls was assigned to the better charge transfer between the bacteria and the more sharpened edges of the reduced nanowalls, during the contact interaction.
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