期刊
ACS NANO
卷 4, 期 4, 页码 2178-2184出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn9015746
关键词
plasmonic nanoparticles; biodegradation of nanoparticles; near-infrared nanoparticles; clearance of nanoparticles; nanoclusters
类别
资金
- National Science Foundation [CHE987664]
- Robert A. Welch Foundation [F-13 9]
- NCI [CA143663]
- NATIONAL CANCER INSTITUTE [R01CA143663] Funding Source: NIH RePORTER
Metal nanoparticles with surface plasmon resonance (SPR) in the near-infrared region (NIR) are of great interest for imaging and therapy. Presently, gold nanoparticles with NIR absorbance are typically larger than 50 nm, above the threshold size of similar to 5 nm required for efficient renal clearance. As these nanoparticles are not biodegradable, concerns about long-term toxicity have restricted their translation into the clinic. Here, we address this problem by developing a flexible platform for the kinetically controlled assembly of sub-5 nm ligand-coated gold particles to produce metal/polymer biodegradable nanoclusters smaller than 100 nm with strong NIR absorbance for multimodal application. A key novel feature of the proposed synthesis is the use of weakly adsorbing biodegradable polymers that allows tight control of nanocluster size and, in addition, results in nanoclusters with unprecedented metal loadings and thus optical functionality. Over time, the biodegradable polymer stabilizer degrades under physiological conditions that leads to disassembly of the nanoclusters into sub-5 nm primary gold particles which are favorable for efficient body clearance. This synthesis of polymer/inorganic nanoclusters combines the imaging contrast and therapeutic capabilities afforded by the NIR-active nanoparticle assembly with the biodegradability of a polymer stabilizer.
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