期刊
ACS NANO
卷 4, 期 7, 页码 3817-3822出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn100464u
关键词
protein drug; nanochannels; block copolymer; single-file diffusion; controlled drug delivery
类别
资金
- National Creative Research Initiative Program
- Ministry of Education, Science and Technology (NEST)
- Korea Institute for Advancement of Technology (KIAT)
- Ministry of Education, Science and Technology [2009-0081871]
- POSCO
- NRF
- National Research Foundation of Korea [2010-50196, 2004-0046408, 20090304101539] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A new drug delivery device using cylindrical block copolymer nanochannels was successfully developed for controlled protein drug delivery applications. Depending on the hydrodynamic diameter of the protein drugs, the pore size in cylindrical nanochannels could be controlled precisely down to 6 nm by Au deposition. Zero-order release of bovine serum albumin (BSA) and human growth hormone (hGH) by single-file diffusion, which has been observed for gas diffusion through zeolite pores, was realized up to 2 months without protein denaturation. Furthermore, a nearly constant in vivo release of hGH from the drug delivery nanodevice implanted to Sprague-Dawley (SD) rats was continued up to 3 weeks, demonstrating the feasibility for long-term controlled delivery of therapeutic protein drugs.
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