期刊
ACS NANO
卷 4, 期 2, 页码 1049-1059出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn901213a
关键词
host-guest interactions; polymer assemblies; multifunctional nanoparticles; drug delivery; gene delivery
类别
资金
- NIH (NIDCR) [DE015384, DE017689]
Novel core-shell structured nanoassemblies are assembled by a beta-cyclodextrin containing a positively charged host polymer and a hydrophobic guest polymer. The hydrophobic core of these types of assemblies serves as a nanocontainer to load and release the hydrophobic drugs, while the positively charged hydrophilic shell is able to condense the plasmid DNA and achieve its transfection/expression in osteoblast cells. These assemblies may be used as a new generation of multifunctional nanocarriers for simultaneous drug delivery and gene therapy.
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