期刊
ACS NANO
卷 4, 期 2, 页码 789-794出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn9015345
关键词
mesoporous materials; nanomaterials; adsorption capacity; endocytosis; cell viability
类别
资金
- U.S. National Science Foundation (NSF) [CHE-0645348]
- Japan Society for the Promotion of Science
We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer platinum drugs when the drugs are combined with (or loaded into) one of the two most common types of mesoporous silica materials, MCM-41 or SBA-15. The anticancer drug cisplatin and its isomer transplatin, when loaded on MCM-41 and SBA-15 microparticles, were less cytotoxic to leukemia cells than the drugs alone after 12 h exposure. However, the drug-loaded microparticles exhibited unprecedented enhanced cytotoxicity to the cancerous cells after 24 h of exposure. This cytotoxicity of the drug-loaded microparticles was even higher than of the pure drugs in solutions, suggesting that mesoporous silica microparticles loaded with cisplatin or transplatin enabled a localized intracellular release of the platinum compounds and possibly also facilitated the drug's hydrolysis, enhancing the desired cytotoxic effect.
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