期刊
ACS NANO
卷 4, 期 5, 页码 2494-2509出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn100634r
关键词
polymers; thin films; sequential deposition; drug delivery; cell adhesion; gene transfer
Polymer films and coatings are among the popular and most successful tools to modulate surface properties of biomaterials, specifically tissue responses and fouling behavior. Over the past decade, a novel opportunity has been widely investigated, namely utility of surface coatings in surface-mediated drug delivery. In these applications, deposited polymer films act as both a coating to modulate surface properties and a reservoir for active therapeutic cargo. The field has recently accelerated beyond the proof-of-concept reports toward delivering practical solutions and established technologies for biomedical applications. This review briefly summarizes the recent successes of polymer thin films, specifically those constructed by sequential polymer deposition technique, in surface-mediated drug delivery.
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