期刊
ACS NANO
卷 4, 期 10, 页码 6267-6277出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn101985a
关键词
boron nitride nanotubes; PC12 cells; piezoelectric stimulation; neuronal regeneration
In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue of their piezoelectric properties, these nanotubes can polarize and convey electrical stimuli to the cells. PC12 stimulated with the present method exhibit neurite sprout 30% greater than the control cultures after 9 days of treatment.
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