期刊
ACS NANO
卷 4, 期 12, 页码 7093-7104出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn100870z
关键词
nanotechnology; cell-based; targeted delivery; magnetic nanoparticles; magnetic hyperthermia; melanoma; neural progenitor cells
类别
资金
- Small Business Innovation Research Development Center (SBIR) of the National Cancer Institute [NIH 1R21CA135599, NSF IIP 0930673, HHSN261200800059C]
- Terry C. Johnson Center for Basic Cancer Research at Kansas State University
- Kansas State University Targeted Excellence
- Kansas State Legislative Appropriation
- Kansas Agricultural Experiment Station
Localized magnetic hyperthermia as a treatment modality for cancer has generated renewed interest, particularly if it can be targeted to the tumor site. We examined whether tumor-tropic neural progenitor cells (NPCs) could be utilized as cell delivery vehicles for achieving preferential accumulation of core/shell iron/ Iron oxide magnetic nanoparticles (MNPs) within a mouse model of melanoma. We developed aminosiloxane - porphyrin functionalized MNPs, evaluated cell viability and loading efficiency, and transplanted neural progenitor cells loaded with this cargo into mice with melanoma. NPCs were efficiently loaded with core/ shell Fe/Fe3O4 MNPs with minimal cytotoxicity; the MNPs accumulated as aggregates in the cytosol. The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors. The tumor attenuation was significant (p < 0.05) a short time (24 h) after the last of three AMF exposures.
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