期刊
ACS NANO
卷 3, 期 2, 页码 418-424出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn800726e
关键词
gold nanoparticle; curvature; DNA-functionalized; gold nanorod; loading
类别
资金
- NSF
- NCI-CCNE
- NIH Director's Pioneer Award
- U.S. Department of Homeland Security (DHS)
- Northwestern University Presidential Fellowship
We show that by correlating the radius of curvature of spherical gold nanoparticles of varying sizes with their respective thiol-terminated oligonucleotide loading densities, a mathematical relationship can be derived for predicting the loading of oligonucleotides on anisotropic gold nanomaterials. This mathematical relationship was tested with gold nanorods (radius 17.5 nm, length 475 nm) where the measured number of oligonucleotides per rod (3330 110) was within experimental error of the predicted loading of 3244 oligonucleotides from the derivation. Additionally, we show that once gold nanoparticles reach a diameter of approximately 60 nm the local surface experienced by the oligonucleotide is highly similar to that of a planar surface.
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