期刊
ACS NANO
卷 3, 期 11, 页码 3529-3536出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn9010768
关键词
Raman spectroscopy; SERS; cells; biosensors; nanoparticles; trace analysis; nanopipette; micropipette
类别
资金
- W.M. Keck Foundation
We report on a new analytical approach to intracellular chemical sensing that utilizes a surface-enhanced Raman spectroscopy (SERS)-enabled nanopipette. The probe is comprised of a glass capillary with a 100-500 nm tip coated with gold nanoparticles. The fixed geometry of the gold nanoparticles allows us to overcome the limitations of the traditional approach for intracellular SERS using metal colloids. We demonstrate that the SERS-enabled nanopipettes can be used for in situ analysis of living cell function in real time. In addition, SERS functionality of these probes allows tracking of their localization in a cell. The developed probes can also be applied for highly sensitive chemical analysis of nanoliter volumes of chemicals in a variety of environmental and analytical applications.
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