期刊
ACS NANO
卷 3, 期 6, 页码 1389-1398出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn900138d
关键词
hyaluronic acid; fluorescence; lymphangiogenesis; quantum dots; surface modification
类别
资金
- Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) [R01-2006-000-10647-0 (2005), R0A-2008-000-20114-0 (2008)]
- Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea [AC60660, A050082]
A simple and novel electrostatic coupling method is reported, which provides a hyaluronic acid-quantum dot conjugate (HA-QD) that is colloidally stable and size-tunable from 50 to 120 nm. The HA-QDs show cancer targeting efficiency, which suggests diagnostic and imaging applications. The conjugates are also demonstrated for the fluorescence staining capability for lymphatic vessels in vitro and in vivo. Using the HA-QDs in a small animal model, lymphatic vessels are visualized real-time in vivo for days. Comprehensive cytotoxicity evaluations are made for the conjugates and the unconjugated counterpart. The HA-QDs showcase the potentials toward cancer imaging and real-time visualization of changes in lymphatic vessels such as lymphangiogenesis.
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