期刊
ACS NANO
卷 3, 期 10, 页码 3200-3206出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn9006362
关键词
single-wall carbon nanotubes; polysaccharide; scaffold; surface properties
类别
资金
- National Science Fund for Distinguished Young Scholars
- National Science Foundation of China [20874059]
- Major Project of Chinese National Programs for Fundamental Research and Development [2009CB930400]
- High Technology Research and Development Program of China [2009AA03Z329]
- Key Fundamental Research Project of Science and Technology Commission of Shanghai Municipal Government [08JC1412300]
- Shanghai Leading Academic Discipline [B202]
Natural polysaccharides such as amylose (AMY), alginate sodium (ALG), and chitosan (CHI) have been noncovalently wrapped onto single-wall carbon nanotubes (SWCNTs) to give a series of SWCNT scaffolds, termed as AMY-SWCNT, ALG-SWCNT, CHI-SWCNT, and CHI/ALG-SWCNT scaffolds. Compared to purified SWCNTs and oxidized SWCNTs, the polysaccharide-wrapped SWCNTs can well mimic nanofibrous extracellular matrix and significantly enhance cell adhesion and proliferation. The surface properties of the SWCNT scaffolds, such as functional groups, surface charge, and hydrophilicity, can all directly influence the protein adsorption and lead to changes in cellular FAK expression, thus affect the mammalian cell morphology and proliferation. By quantitatively studying the surface properties of these SWCNT scaffolds, it can be concluded that relatively positively charged hydrophilic scaffolds that bear -OH groups can remarkably promote cell growth. Considering all properties, the relatively electrical neutral and hydrophilic AMY-SWCNT scaffolds bearing only -OH groups ate able to sustain the highest cell viability after 72 h culturing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据