期刊
ACS NANO
卷 4, 期 1, 页码 181-188出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn901226h
关键词
self-assembly; peptide; template; sol-gel; hybrid materials
类别
资金
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CHl 1357]
- National Health Institute [ROI DE016386-01]
- Army Research Laboratories [CCMT332157]
- National Institute of Standards and Technology
- NATIONAL CANCER INSTITUTE [ZIABC011313] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE016386] Funding Source: NIH RePORTER
Self-assembly represents a robust and powerful paradigm for the bottom-up construction of nanostructures. Templated condensation of silica precursors on self-assembled nanoscale peptide fibrils with various surface functionalities can be used to mimic biosilicification. This template-defined approach toward biomineralization was utilized for the controlled fabrication of 3D hybrid nanostructures. The peptides MAX1 and MAX8 used herein form networks consisting of Interconnected, self-assembled P-sheet fibrils, We report a study on the structure-property relationship of self-assembled peptide hydrogels where mineralization of individual fibrils through sol-gel chemistry was achieved. The nanostructure and consequent mechanical characteristics of these hybrid networks can be modulated by changing the stoichiometric parameters of the sol-gel process. The physical characterization of the hybrid networks via electron microscopy and small-angle scattering is detailed and correlated with changes in the network mechanical behavior. The resultant high fidelity templating process suggests that the peptide substrate can be used to template the coating of other functional inorganic materials.
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