期刊
PSYCHIATRIC CLINICS OF NORTH AMERICA
卷 34, 期 2, 页码 403-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.psc.2011.02.010
关键词
Geriatric depression; PET; fMRI; Spectroscopy
类别
资金
- NIMH NIH HHS [K23 MH074818, K23MH74818, MH 64823, R01 MH086881-03, K02 MH001621, MH 86881, R01 MH064823, K23 MH074818-05, MH01621, R01 MH086881, R01 MH064823-05, K02 MH001621-11] Funding Source: Medline
Abnormalities in specific cerebral networks likely confer vulnerability that increases the susceptibility for development of geriatric depression and affect the course of symptoms. Functional neuroimaging enables the in vivo identification of alterations in cerebral function that characterize disease vulnerability and contribute to variability in depressive symptoms and antidepressant response. Judicious use of functional neuroimaging tools can advance pathophysiologic models of geriatric depression. Furthermore, geriatric depression provides a logical context within which to study the role of specific functional abnormalities in both antidepressant response and key behavioral and cognitive abnormalities of mood disorders.
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