期刊
ACS NANO
卷 2, 期 11, 页码 2273-2282出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn8004476
关键词
nanoparticles; polysiloxane shell; bioconjugation; streptavidin; fibronectin
类别
资金
- Agence Nationale de la Recherche [ANR-05-NANO-037-02]
For labeling proteins (streptavidin and fibronectin) by luminescent aminated nanoparticles, an interesting strategy that requires neither activation nor chemical pre- or post-treatment was explored. Because biomolecules are easily rendered luminescent after reaction with organic dyes carrying isothiocyanate moiety, phenylene diisothiocyanate (DITC) was used for covalently binding proteins onto luminescent hybrid gadolinium oxide nanoparticles whose ability to combine imaging and therapy was recently demonstrated.
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