期刊
IMMUNOLOGY LETTERS
卷 164, 期 2, 页码 65-71出版社
ELSEVIER
DOI: 10.1016/j.imlet.2015.02.007
关键词
Clostridium difficile toxin B; Reactive oxygen species; Immunogenic cell death; Apoptosis
类别
资金
- Innovative Programme of Department of education of Guangdong Province [2013KJCX0013]
- China Postdoctoral Science Foundation [2012M521593, 2013T60796]
Immunogenic cell death (ICD) is a new concept appeared in recent years. Despite growing interests of research on ICD, the circumstances that trigger immune responses against dying tumor cells remain largely unknown. It was demonstrated that recombinant Clostridium difficile toxin B (rTcdB) can induce ICD in intoxicated cells, but its mechanism remains unclear. This work aims at exploring whether reactive oxygen species (ROS) involved in rTcdB induced ICD using the chemical agent N-acetyl cysteine (NAC), diphenylene iodonium (DPI) and Antimycin A (Anti.A). The results suggested that ROS involved in rTcdB induced apoptosis and autophagy. DPI and Anti.A successfully inhibited the antitumor immune effect induced by rTcdB. As ICD is determined by a variety of factors, rTcdB is a potential tool for further exploring the circumstances that trigger ICD, which may offer us a good choice for designing the new chemotherapeutic drugs with immunogenic properties. (C) 2015 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
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