期刊
ACS CHEMICAL NEUROSCIENCE
卷 5, 期 12, 页码 1178-1191出版社
AMER CHEMICAL SOC
DOI: 10.1021/cn500148z
关键词
Tau oligomers; aggregation; neurodegeneration; Alzheimer's disease; protein spreading; synaptic impairment; new drug targets; proteasome; autophagy
资金
- National Research Council (CONACYT), Mexico City [203584]
Most neurodegenerative diseases are characterized by the presence of protein aggregates. Alzheimer's disease (AD) is the most common cause of dementia in people over age 60. One of the histopathological hallmarks of AD is the presence of tau protein aggregates. Historically, it has been thought that paired helical filaments (PHFs) were the toxic form of tau that assembled to form neurofibrillary tangles (NFTs), but recently there has been evidence that tau oligomers, which form before PHFs and NFTs, could be the structures mediating neurodegeneration even before the fibrillary tau is deposited. Here, we discuss the recent advances in tau oligomer research, their implications on AD and other tauopathies, the mechanisms of tau turnover by the principal protein clearance systems (the proteasome and autophagy), and the potential use of tau oligomers as drug targets for the development of new therapeutic approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据