期刊
ACS CHEMICAL NEUROSCIENCE
卷 5, 期 4, 页码 253-260出版社
AMER CHEMICAL SOC
DOI: 10.1021/cn5000056
关键词
Diazepam; Valium; benzodiazepine; GABA; anxiety; hypnotic; sedative
Diazepam (Valium) is among the most successful drugs from the onset of the psychopharmacological revolution that began during the 1950s. Efficacious in treating a wide-spectrum of CNS disorders, including anxiety and epilepsy, it set the standard for pharrnacotherapy in terms of potency, onset of action, and safety. In this Review, the legacy of diazepam to chemical neuroscience will be considered along with its synthesis, pharmacology, drug metabolism, adverse events and dependence, clinical use, and regulatory issues.
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