期刊
IMMUNOLOGY LETTERS
卷 168, 期 2, 页码 129-135出版社
ELSEVIER
DOI: 10.1016/j.imlet.2015.06.020
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资金
- La Caixa-Severo Ochoa PhD fellowship
- Boehringer Ingelheim Fonds
- Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III
- Spanish Ministry of Economy and Competitiveness (TerCel, Spanish Cell Therapy Network)
- Spanish Ministry of Economy and Competitiveness (Plan Nacional grant) [SAF-2011-30308]
- Spanish Ministry of Economy and Competitiveness (Ramon y Cajal Program) [RYC-2009-04703]
- Marie Curie Career Integration Programme grant [FP7-PEOPLE-2011-RG-294096]
- ConSEPOC-Comunidad de Madrid grant [S2010/BMD-2542]
- International Early Career Scientist grant of the Howard Hughes Medical Institute
Recent discoveries have significantly expanded our previous knowledge about the role of bone marrow mesenchymal stem cells (BMSCs) in hematopoiesis. BMSCs and their derivatives modulate blood production and immunity at different levels but a prominent role has emerged for BMSCs in the regulation of hematopoietic stem and progenitor cells (HSPCs). Additionally, BMSC-like cells regulate B and T cell lymphopoiesis and also probably myelopoiesis. Furthermore, BMSCs might also exhibit key regulatory properties in non-physiological conditions. BMSCs in extramedullary sites might provide a permissive microenviroment to allow for transient hematopoiesis. BMSCs might be also involved in the manifestation and/or the development of hematopoietic diseases, as stemming from their emerging roles in the progression of hematological malignancies. Here we review some key molecular pathways, adhesion molecules and ligand/receptor interactions that mediate the crosstalk between BMSCs and hematopoietic stem cells (HSCs) in health and disease. The development of novel markers to visualize and isolate individual cells will help to dissect the stromal-hematopoietic interplay. Crown Copyright (C) 2015 Published by Elsevier B.V. All rights reserved.
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