期刊
ACS CHEMICAL NEUROSCIENCE
卷 5, 期 5, 页码 335-339出版社
AMER CHEMICAL SOC
DOI: 10.1021/cn500054n
关键词
Carborane; blood-brain barrier; P2X(7); polycycle; antidepressant
资金
- NHMRC
- European Union's Seventh Framework Programme - INMiND [HEALTH-F2-2011-278850]
Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs center dot 5) exerts a significant biological effect as an inhibitor of the purinergic P2X(7) receptor (P2X(7)R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to modify CNS activity. [GRAPHICS]
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