期刊
ACS CHEMICAL NEUROSCIENCE
卷 4, 期 5, 页码 648-651出版社
AMER CHEMICAL SOC
DOI: 10.1021/cn4000956
关键词
neurotransmitter release; fluorescent imaging; FFNs; optical tracers; neurotransmitter sensors; brain activity maps
资金
- NIDA NIH HHS [DA010154, R01 DA007418, DA07418] Funding Source: Medline
- NIMH NIH HHS [MH086545] Funding Source: Medline
To advance understanding of the brain, the ability to measure both nerve cell electrical spiking and chemical neurotransmission with high spatial resolution is required. In comparison to the development of voltage sensors and Ca2+ indicator dyes over the past several decades, high resolution imaging of neurotransmitter (NT) release at single synapses has not been possible. In this Viewpoint, we discuss two recent developments toward this goal, namely, the design of fluorescent false neurotransmitters (FFNs) and optical neurotransmitter sensors.
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