期刊
ACS CHEMICAL NEUROSCIENCE
卷 1, 期 4, 页码 279-287出版社
AMER CHEMICAL SOC
DOI: 10.1021/cn900027u
关键词
Amyloid; aggregation kinetics; nanoparticles
资金
- Irish Research Council for Science, Engineering and Technology
- Xunta de Galicia
- EU [NMP4-CT-2006-033231]
- SFI SRC BioNanoInteract [07 SRC B1155]
- Swedish Research Council
- Linneaus Centre Organizing Molecular Matter (Lund, Sweden)
- Crafoord Foundation (Lund, Sweden)
- EPA [2007-FS-EH7-M5-R2]
- Science Foundation Ireland (SFI) [07/SRC/B1155] Funding Source: Science Foundation Ireland (SFI)
The fibrillation kinetics of the amyloid beta peptide is analyzed in presence of cationic polystyrene nanoparticles of different size. The results highlight the importance of the ratio between the peptide and particle concentration. Depending on the specific ratio, the kinetic effects vary from acceleration of the fibrillation process by reducing the lag phase at low particle surface area in solution to inhibition of the fibrillation process at high particle surface area. The kinetic behavior can be explained if we assume a balance between two different pathways: first fibrillation of free monomer in solution and second nucleation and fibrillation promoted at the particle surface. The overall rate of fibrillation will depend on the interplay between these two pathways, and the predominance of one mechanism over the other will be determined by the relative equilibrium and rate constants.
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