期刊
ACS CHEMICAL NEUROSCIENCE
卷 2, 期 1, 页码 17-25出版社
AMER CHEMICAL SOC
DOI: 10.1021/cn100085g
关键词
Itch; pain; DRG neurons; skin; spinal cord; Mrgpr; GRPR; histamine; TRP
资金
- NATIONAL EYE INSTITUTE [T32EY017203] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM087369] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS054791] Funding Source: NIH RePORTER
- NEI NIH HHS [T32 EY017203] Funding Source: Medline
- NIGMS NIH HHS [R01 GM087369-01A1, R01 GM087369] Funding Source: Medline
- NINDS NIH HHS [R01 NS054791-06, R01 NS054791] Funding Source: Medline
The itch field has made great advances in recent years, building upon earlier work to form a clearer picture of the biology behind this important sensory modality. Models for how itch is encoded have emerged that fit with physiological, molecular, and behavioral data. The molecular mechanisms of itch, both peripherally and centrally, are being revealed with the aid of newer animal models. Future work must address shortcomings in our current understanding of itch including limitations of current experimental methods. Here we review what is known about the cells, molecules, and circuits involved in itch and highlight key questions that remain to be answered.
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