期刊
ACS CHEMICAL BIOLOGY
卷 9, 期 9, 页码 1969-1974出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb500313f
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资金
- Netherlands Organization for Scientific Research (NWO-CW)
- Royal Netherlands Academy of Arts and Sciences Science (KNAW)
- European Research Council (ERC) [227897]
- Ministry of Education, Culture and Science [024.001.035]
Selection of a single bacterial strain out of a mixture of microorganisms is of crucial importance in healthcare and microbiology research. Novel approaches that can externally control bacterial selection are a valuable addition to the microbiology toolbox. In this proof-of-concept, two complementary antibiotics are protected with photocleavable groups that can be orthogonally addressed with different wavelengths of light. This allows for the light-triggered selection of a single bacterial strain out of a mixture of multiple strains, by choosing the right wavelength. Further improvement toward additional orthogonally addressable antibiotics might ultimately lead to a novel methodology for bacterial selection in complex populations.
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