期刊
ACS CHEMICAL BIOLOGY
卷 9, 期 7, 页码 1398-1407出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb500176x
关键词
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资金
- University of Pittsburgh
- National Science Foundation [MCB-1330746]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1330746] Funding Source: National Science Foundation
Biological processes are naturally regulated with high spatial and temporal resolution at the molecular, cellular, and systems level. To control and study processes with the same resolution, light-sensitive groups and domains have been employed to optically activate and deactivate protein function. Optical control is a noninvasive technique in which the amplitude, wavelength, spatial location, and timing of the light illumination can be easily controlled. This review focuses on applications of genetically encoded unnatural amino acids containing light-removable protecting groups to optically trigger protein function, while also discussing select optogenetic approaches using natural light-sensitive domains to engineer optical control of biological processes.
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