期刊
ACS CHEMICAL BIOLOGY
卷 9, 期 8, 页码 1674-1679出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb500286b
关键词
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资金
- Italian Association for Cancer Research (AIRC): Emilia-Romagna AIRC Start-up grant [6266]
- AIRC Start-up grant [4841]
Argonaute proteins are pivotal regulators of gene expression mediating miRNAs function. Modulating their activity would be extremely useful to elucidate the processes governing small-RNAs-guided gene silencing. We report the identification of a chemical compound able to compete with Argonaute 2 miRNAs binding, and we demonstrate that this functional inhibition determines effects similar to Argonaute 2 shRNA-mediated down-regulation, favoring granulocytic differentiation of the acute promyelocytic leukemia cell line NB4 in response to retinoic acid.
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