期刊
ACS CHEMICAL BIOLOGY
卷 9, 期 9, 页码 1980-1984出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb5004338
关键词
-
资金
- National Institutes of Health (NIH) [P01-ES021921]
- National Science Foundation (NSF) through Oceans and Human Health program, NIH [OCE-1313747, S10-RR031562]
- Helen Hay Whitney Foundation
- Directorate For Geosciences
- Division Of Ocean Sciences [1313747] Funding Source: National Science Foundation
Polyhalogenated dibenzo-p-dioxins are arguably among the most toxic molecules known to man. In addition to anthropogenic sources, marine invertebrates also harbor polybrominated dibenzo-p-dioxins of as yet unknown biogenic origin. Here, we report that the bmp gene locus in marine bacteria, a recently characterized source of polybrominated diphenyl ethers, can also synthesize dibenzo-p-dioxins by employing different phenolic initiator molecules. Our findings also diversify the structural classes of diphenyl ethers accessed by the mmp biosynthetic pathway. This report lays the biochemical foundation of a likely biogenetic origin of dibenzo-p-dioxins present in the marine metabolome and greatly expands the toxicity potential of marine derived polyhaloganated natural products.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据