期刊
ACS CHEMICAL BIOLOGY
卷 9, 期 3, 页码 831-837出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb4003305
关键词
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资金
- NCI NIH HHS [R01 CA050239, 5R01CA050239, R01 CA178394, K08 CA151450] Funding Source: Medline
- NIGMS NIH HHS [5R01GM090299, R01 GM090299] Funding Source: Medline
Hydrocarbon stapling is a chemical approach to restoring and fortifying the natural a-helical structure of peptides that otherwise unfold when taken out of context from the host protein. By iterating the peptide sequence, staple type, and sites of insertion, discrete compositions can be generated to suit a diversity of biochemical, structural, proteomic, cellular, and drug development applications. Here, we reinforce key design considerations to avoid pitfalls and maximize progress when applying stapled peptides in chemistry and biology research.
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