期刊
ACS CHEMICAL BIOLOGY
卷 9, 期 1, 页码 111-115出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb400755b
关键词
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资金
- National Institutes of Health [R01 GM073046, DP1 HD075622]
- Human Frontiers Science Program (HFSP) fellowship
Post-translational regulation of protein abundance in cells is a powerful tool for studying protein function. Here, we describe a novel genetically encoded protein domain that is degraded upon exposure to nontoxic blue light. We demonstrate that fusion proteins containing this domain are rapidly degraded in cultured cells and in zebrafish upon illumination.
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