期刊
ACS CHEMICAL BIOLOGY
卷 8, 期 10, 页码 2151-2156出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb400505a
关键词
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资金
- BBSRC
- IMRC Wealth out of waste Project
- BBSRC IBTI Refinery Club [BB/H004270/1]
- Genome Canada [LSARP 2108]
- BBSRC [BB/H004270/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/H004270/1] Funding Source: researchfish
The aromatic polymer lignin represents a possible renewable source of aromatic chemicals, if biocatalytic routes for lignin breakdown can be developed. The availability of a genome sequence for Rhodococcus jostii RHA1, a bacterium that breaks down lignin, has allowed the application of a targeted pathway engineering strategy to lignin breakdown to produce vanillin, a valuable food/flavor chemical. A gene deletion strain of R. jostii RHA1 in which the vanillin dehydrogenase gene had been deleted, when grown on minimal medium containing 2.5% wheat straw lignocellulose and 0.05% glucose, was found to accumulate vanillin with yields of up to 96 mg/L after 144 h, together with smaller amounts of ferulic acid and 4-hydroxybenzaldehyde.
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