期刊
ACS CHEMICAL BIOLOGY
卷 8, 期 12, 页码 2771-2777出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb4007024
关键词
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资金
- NIH [GM090259]
- NSF [CHE-1213596, DGE-0965843]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1213596] Funding Source: National Science Foundation
Aminoglycosides are broad-spectrum antibiotics that are used for the treatment of severe Gram-negative and Gram-positive bacterial infections. While bactericidal effects of aminoglycosides are due to binding to the 30S subunit of the bacterial ribosome, aminoglycosides can affect protein synthesis, intracellular calcium levels, and levels of reactive oxygen species (ROS) in eukaryotic cells. While aminoglycosides can be cytotoxic at high concentrations, our results show that at much lower doses, gentamicin can be implemented as a sensitizing agent for the NSCLC cell line NCI-H460, increasing the efficacy of camptothecin, digitoxin, and vinblastine in vitro. We have also established that this sensitization is reliant on the ROS response generated by gentamicin.
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