期刊
ACS CHEMICAL BIOLOGY
卷 7, 期 6, 页码 967-972出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb300059z
关键词
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资金
- PharmSelex
- Tri-Institutional Training Program in Chemical Biology
G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce signals. Although GPCRs represent the largest class of therapeutic targets, only a small percentage of their ligand-binding sites are precisely defined. Here we describe the novel application of targeted photo-cross-linking using unnatural amino acids to obtain structural information about the allosteric binding site of a small molecule drug, the CCR5-targeted HIV-1 co-receptor blocker maraviroc.
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