期刊
ACS CHEMICAL BIOLOGY
卷 7, 期 10, 页码 1647-1652出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb300331z
关键词
-
资金
- Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative
Agonism of insect odorant receptor (OR) cation channels may represent a new strategy for the manipulation of destructive insect olfactory-driven behaviors. We have explored the chemical space around VUAA1, the first in class agonist of the obligate OR co-receptor ion channel (Orco), and describe novel compound analogues with increased potency across insect taxa. Functional analyses reveal several of these VUAA1 structural analogues display significantly greater potency as compared to the activity of the previously described active compounds in mobility-based behavioral assays on mosquito larvae.
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