期刊
ACS CHEMICAL BIOLOGY
卷 7, 期 5, 页码 817-821出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb200478t
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资金
- Swiss National Science Foundation (SNSF) [PP00P3_123524/1]
- Medical Research Council [MC_U105115240] Funding Source: researchfish
- MRC [MC_U105115240] Funding Source: UKRI
From a large combinatorial library of chemically constrained bicyclic peptides we isolated a selective and potent (K-i = 53 nM) inhibitor of human urokinase-type plasminogen activator (uPA) and crystallized the complex. This revealed an extended structure of the peptide with both peptide loops engaging the target to form a large interaction surface of 701 angstrom(2) with multiple hydrogen bonds and complementary charge interactions, explaining the high affinity and specificity of the inhibitor. The interface resembles that between two proteins and suggests that these constrained peptides have the potential to act as small protein mimics.
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