期刊
ACS CHEMICAL BIOLOGY
卷 6, 期 12, 页码 1314-1320出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb200155t
关键词
-
资金
- National Institutes of Health [R01 HG003541, R01 GM30518, U54 CAl21852]
- USC
DNA shape variation and the associated variation in minor groove electrostatic, potential are widely exploited by proteins for DNA recognition. Here we show that the hydroxyl radical cleavage pattern is a quantitative measure of DNA backbone solvent accessibility, minor groove width, and minor groove electrostatic potential, at single nucleotide resolution. We introduce maps of DNA shape and electrostatic potential as tools for understanding how proteins recognize binding sites in a genome. These maps reveal periodic structural signals in yeast and Drosophila genomic DNA sequences that are associated with positioned nucleosomes.
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