期刊
ACS CHEMICAL BIOLOGY
卷 5, 期 1, 页码 139-148出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb900278x
关键词
5 '-UTR; Chemotaxis; RNA aptamer; NAND logic gate; NOR logic gate; Riboswitch; Ribozyme riboswitch; SELEX
资金
- National Institutes of Health [GM074070]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM074070] Funding Source: NIH RePORTER
Living systems use RNA sequences known as riboswitches to detect the concentrations of small-molecule metabolites within cells and to regulate the expression of genes that produce these metabolites. Like their natural counterparts, synthetic riboswitches also regulate gene expression in response to small molecules. Because synthetic riboswitches can be engineered to respond to non-endogenous small molecules, they are powerful tools for chemical and synthetic biologists interested in understanding and reprogramming cellular behavior. In this review, we present an overview of natural riboswitches, highlight recent studies toward developing synthetic riboswitches and provide an overview of emerging applications of these RNA switches in chemical biology.
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