期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 41, 页码 34840-34848出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b12897
关键词
CS-AuNPs-DOX; target drug delivery; fluorescence imaging; glutathione (GSH); cell apoptosis
资金
- National Natural Science Foundation of China [21375070, 21422504]
- Fund Project for Shangdong Key RD Program [2017GGX20121]
- Key Laboratory of Spectrochemical Analysis & Instrumentation (Xiamen University), Ministry of Education [SCAI1702, SCAI1703]
Drug delivery system has a profound significance for imaging capabilities and monitoring apoptosis process precisely in cancer therapeutic field. Herein, we designed cysteamine (CS)-stabilized gold nanoparticles, CS-gold nanoparticles (AuNPs)-doxorubicin (DOX), for fluorescence-enhanced cell imaging and target drug delivery. For cancer therapy, DOX was incorporated to CS-AuNPs by disulfide linkages which could be cleaved by glutathione (GSH) in cancer cells specifically. In addition, red-emissive DOX was quenched effectively by particular quenching effect of fluorescence resonance energy transfer from DOX to AuNPs, rendering monitoring target drug release by visual luminescence. The released DOX-SH acted as an indicator for cancer cells with red fluorescence and was further used for stimuli-responsive drug therapy. After an overall investigation of detection for GSH, proapoptosis for cancer cells, and inhibition for tumor tissues in vivo, the CS-AuNPs-DOX nanoprobe shows an obviously enhanced performance. This proposal provides an intelligent strategy for cell imaging and drug delivery, which serves as a promising candidate for anticancer therapeutic applications.
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