期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 40, 页码 33901-33912出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b10207
关键词
honeycomb MnO2; upconversion; ROS; photodynamic therapy; bioimaging
资金
- National Natural Science Foundation of China [NSFC 51772059, 51472058, 51602072]
- Special Innovation Talents of Harbin Science and Technology [2016RAXXJ005]
- Fundamental Research funds for the Central Universities
- Research Fund for Key Laboratory of the Ministry of Education for Advanced Catalysis Materials
The oxygen-deprived environment of a solid tumor is still great restriction in achieving an efficient photodynamic therapy (PDT). In this work, we developed a smart pH-controllable and H2O2-responsive nanoplatform with degradable property, which was based on honeycomb manganese oxide (hMnO(2)) nanospheres loaded with Ce6-sensitized core-shell-shell structured up-conversion nanoparticles (NaGdF4:Yb/Er,Tm@NaGdF4:Yb@NaNdF4:Yb) (abbreviated as hMUC). In the system, the speedy breakup of the as-prepared hMnO(2) nanostructures results in release of loaded Ce6-sensitized UCNPs under the condition of H2O2 in acid solution. When exposed to tissue-penetrable 808 nm laser, up-conversion nanoparticles (UCNPs) emit higher-energy visible photons which would be absorbed by Ce6 to yield cytotoxic reactive oxygen species (ROS), thus triggering PDT treatment naturally. Moreover, the in vitro and in vivo experiments demonstrate that hMUC sample with the honeycomb-satellite structure can serve as multimodal bioimaging contrast agent for self-enhanced upconversion luminescence (UCL), magnetic resonance imaging (MRI) and computed tomography (CT) imaging, indicating that the as-prepared hMUC could be used in imaging-guided diagnosis and treatment, which has a potential application in the PDT treatment of tumor.
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