期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 39, 页码 33523-33531出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b10064
关键词
self-healing hydrogel; mechanical toughness; tissue adhesiveness; mussel-inspired; wound dressing
资金
- Natural Science Foundation of China (NSFC) [U1733130, 11704244]
- Shanghai Sailing Plan Project [16YF1406100]
- Shanghai Natural Science Funding [17ZR1441000]
- Medical-Engineering Cross Research Funding of SJTU [YG2017MS01]
- Basic Research Field of Shanghai Science and Technology Innovation Program [16JC1401500]
- Shanghai Science and Technology Innovation Action Plan [18511109000]
A hydrogel for potential applications in wound dressing should possess several peculiar properties, such as efficient self-healing ability and mechanical toughness, so as to repair muscle and skin damage. Additionally, excellent cell affinity and tissue adhesiveness are also necessary for the hydrogel to integrate with the wound tissue in practical applications. Herein, an ultratough and self-healing hydrogel with superior cell affinity and tissue adhesiveness is prepared. The self-healing ability of the hydrogel is obtained through hydrogen bonds and dynamic Schiff cross-linking between dopamine-grafted oxidized sodium alginate (OSA-DA) and polyacrylamide (PAM) chains. The covalent cross-linking is responsible for its stable mechanical structure. The combination of physical and chemical cross-linking contributes to a novel hydrogel with efficient self healing ability (80% mechanical recovery in 6 h), high tensile strength (0.109 MPa), and ultrastretchability (2550%), which are highly desirable properties and are superior to previously reported tough and self-healing hydrogels for wound dressing applications. More remarkably, due to plenty of catechol groups on the OSA-DA chains, the hydrogel has unique cell affinity and tissue adhesiveness. Moreover, we demonstrate the practical utility of our fabricated hydrogel via both in vivo and in vitro experiments.
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