期刊
ACS APPLIED MATERIALS & INTERFACES
卷 6, 期 24, 页码 22209-22215出版社
AMER CHEMICAL SOC
DOI: 10.1021/am505849e
关键词
thread; microfluidics; chromatographic separation; surface morphology; weak ABO blood typing
资金
- Australian Research Council [ARC DP1094179, ARC LP1120973]
- Monash University
- Department of Chemical Engineering
Thread-based microfluidics research has so far focused on utilizing and manipulating the wicking properties of threads to form controllable microfluidic channels. In this study we aim to understand the separation properties of threads, which are important to their microfluidic detection applications for blood analysis. Confocal microscopy was utilized to investigate the effect of the microscale surface morphologies of fibers on the thread's separation efficiency of red blood cells. We demonstrated the remarkably different separation properties of threads made using silk and cotton fibers. Thread separation properties dominate the clarity of blood typing assays of the ABO groups and some of their weak subgroups (A(x) and A(3)). The microfluidic thread-based analytical devices (mu TADs) designed in this work were used to accurately type different blood samples, including 89 normal ABO and 6 weak A subgroups. By selecting thread with the right surface morphology, we were able to build mu TADs capable of providing rapid and accurate typing of the weak blood groups with high clarity.
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