期刊
ACS APPLIED MATERIALS & INTERFACES
卷 6, 期 11, 页码 8878-8885出版社
AMER CHEMICAL SOC
DOI: 10.1021/am501608c
关键词
Pd-PEI-Ce6 nanocomposite; photothermal therapy; photodynamic therapy; combinational therapy; in vivo
资金
- National Natural Science Foundation of China [21101131]
- National Basic Research Foundation (973) of China [2014CB932004]
- Natural Science Foundation of Fujian Province [2012J01056]
- Fundamental Research Funds for the Central Universities [2010121015]
- State Key Laboratory of Chemo/biosensing and Chemometrics [2013009]
In this work, we prepared chlorin e6 (Ce6)-functionalized Pd nanosheets (Pd-PEI-Ce6) for the photodynamic and photothermal combined therapy that use a single laser. To fabricate the Pd-PEI-Ce6 nanocomposite, photosensitizer Ce6 were chemically conjugated to polyethylenimine (PEI) and the formed Ce6-PEI conjugates were then anchored onto Pd nanosheets by electrostatic and coordination interaction. The prepared Pd-PEI-Ce6 nanocomposite were about 4.5 nm in size, exhibited broad, and strong absorption from 450 to 800 nm, good singlet oxygen generation capacity and photothermal conversion efficiency, and excellent biocompability. Significantly greater cell killing was observed when He La cells incubated with Pd-PEI-Ce6 were irradiated with the 660 nm laser, attributable to both Pd nanosheets-mediated photothermal ablation and the photodynamic destruction effect of photosensitizer Ce6. The double phototherapy effect was also confirmed in vivo. It was found that the Pd-PEI-Ce6 treated tumor-bearing mice displayed the enhanced therapeutic efficiency compared to that of Pd-PEI, or Ce6-treated mice. Our work highlights the promise of using Pd nanosheets for potential multimode cancer therapies.
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