期刊
ACS APPLIED MATERIALS & INTERFACES
卷 6, 期 22, 页码 19850-19857出版社
AMER CHEMICAL SOC
DOI: 10.1021/am505223t
关键词
manganese oxide nanoparticles (MnO NPs); tiny brain glioma; magnetic resonance imaging (MRI); folic acid (FA)
资金
- Natural Science Foundation of China [81271639, 81372694]
- Beijing Municipal Foundation for the Talents [2011D005018000001]
- Capital Medical University [13JL02]
- Open Project Program of Key Laboratory for Neurodegenerative Diseases of the Ministry of Education [2012NZDJ01]
- Beijing Sanbo Brain Hospital Advance research program of innovation [2012SJ005]
Detection of brain gliomas at the earliest stage is of great importance to improve outcomes, but it remains a most challenging task. In this study, oleic acid capped manganese oxide (MnO) nanoparticles (NPs) were prepared by the thermal decomposition of manganese oleate precursors and then transformed to water-dispersible MnO NPs by replacing oleic acid with N-(trimethoxysilylpropyl) ethylene diamine triacetic acid (TETT) silane. The covalently bonded TETT silane offers MnO NPs colloidal stability and abundant carboxylic functional groups allowing the further conjugation of the glioma-specific moiety, folic acid (FA). Moreover, the thin layer of TETT silane ensures a short distance between external Mn ion and water proton, which endows the FA-conjugated, TETT modified MnO (MnO-TETT-FA) NPs a longitudinal relaxivity as high as 4.83 mM(-1) s(-1). Accordingly, the in vivo magnetic resonance (MR) images demonstrated that MnO-TETT-FA NPs could efficiently enhance the MRI contrast for tiny brain gliomas. More importantly, due to the specificity of FA, MnO-TETT-FA NPs led to a clearer margin of the tiny glioma. This together with the good biocompatibility discloses the great potential of MnO-TETT-FA NPs as effective MRI contrast agents for the early diagnosis of brain gliomas.
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