期刊
ACS APPLIED MATERIALS & INTERFACES
卷 6, 期 13, 页码 10783-10791出版社
AMER CHEMICAL SOC
DOI: 10.1021/am502282f
关键词
aggregation-induced emission; long circulation lifetime; dual-modal MRI contrast agent; teraphenylethene derivatives; cell imaging
资金
- National Basic Research Program of China (973 Program) [2013CB834701]
- Research Grants Council of Hong Kong [HKUST2/CRF/10, N_HKUST620/11]
- University Grants Committee of Hong Kong [AoE/P-03/08]
- Guangdong Innovative Research Team Program [201101C0105067115]
We herein report a novel dual-modal MRI contrast agent, TPE-2Gd, for both magnetic and fluorescence imaging. TPE-2Gd consists of a hydrophobic tetraphenylethene (TPE) fluorophore and two hydrophilic gadolinium (Gd) diethylenetriaminepentaacetic acid moieties. As an amphiphilic molecule, TPE-2Gd aggregates into micelles at a high concentration in aqueous medium. These aggregates are highly emissive, showing an aggregation-induced emission (AIE) characteristic. TPE-2Gd is used as a fluorescent agent for cell imaging, which demonstrates negligible cytotoxicity and excellent photostability owing to its AIE property. As a magnetic resonance imaging (MRI) contrast agent, TPE-2Gd exhibits similar longitudinal relaxivity in water (R-1,R-TPE-2Gd = 3.36 +/- 0.10 s(-1) per mM of Gd3+) as those commercial agents (e.g., Magnevist, R-1,R-magnevist = 3.70 +/- 0.02 s(-1) per mM of Gd3+). Compared with Magnevist, the circulation lifetime of TPE-2Gd nanoaggregates in living rats is extended from 10 min to 1 h. With relatively high specificity to the liver, the MR imaging could remain hyperintense in liver even after 150 min post injection. These TPE-2Gd nanoparticles can be excreted gradually via renal filtration due to the disassembly of the nanoparticles into small molecules during circulation. TPE-2Gd could thus potentially be used as a liver specific MRI contrast agent for clinical diagnosis.
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